Neostigmine methyl sulfate 51-60-5 anticholinesterase agent cholinesterase inhibitor

We supply good quality Neostigmine methyl sulfate 51-60-5

Introduction

Neostigmine Methylsulfate, an anticholinesterase agent, is a bitter tasting, white crystalline powder and is very soluble in water and soluble in alcohol. Neostigmine Methylsulfate, USP is a sterile, nonpyrogenic solution intended for intramuscular, subcutaneous or slow intravenous use.

A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.

Application

Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. The drug inhibits acetylcholinesterase which is responsible for the degredation of acetylcholine. So, with acetylcholinesterase inhibited, more acetylcholine is present By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors which are involved in muscle contraction.. It does not cross the blood-brain barrier.

Neostigmine Methylsulfate, USP is indicated for:

- the symptomatic control of myasthenia gravis when oral therapy is impractical.
- the prevention and treatment of postoperative distention and urinary retention after mechanical obstruction has been excluded.
- reversal of effects of non-depolarizing neuromuscular blocking agents (e.g., tubocurarine, metocurine, gallamine or pancuronium) after surgery.

Basic information

•  Appearance: Crystalline Solid
•  Molecular Weight: 334.43
•  Boiling Point: 457
•  Melting Point: 175-177 °C(lit.)
•  Flash Point: 224
•  Storage Temperature: −20°C
•  Solubility: 1g/10mL in water
•  Stability: Stable at normal temperatures and pressures.

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