Health care products, food additives, cosmetics additives, plastic additives
|Place of Origin:||CHINA|
|Brand Name:||Health Herb|
|Minimum Order Quantity:||25KGS|
|Delivery Time:||7 DAYS|
|Function:||Health Food, Sport Nutrition||Series:||Carnitine|
sodium gluconate powder,
vitamins raw materials
We supply Supplement raw materials L-Carnitine-L-tartrate.
L-Carnitine-L-tartrate can be used for drugs and health products, sports beverage, infant food and animal feed.
|Packing||In cardboard drum, 25kgs/drum(net wt)|
|Appearance||white crystal or crystalline powder|
There are two types of carnitine deficiency, primary and secondary carnitine deficiency. Under these circumstances there is a specific and scientific value of carnitine intake. Primary carnitine deficiency is a genetic disorder of the cellular carnitine-transporter system that typically appears by the age of five with symptoms of cardiomyopathy, skeletal-muscle weakness, and hypoglycemia. Secondary carnitine deficiencies may happen as the result of certain disorders such as chronic renal failure, or under conditions that reduce carnitine absorption or increase its excretion, for example taking antibiotics, malnutrition, and poor absorption.
Some research has been carried out on carnitine supplementation in athletes, given its role in fatty acid metabolism; however, individual responses varied significantly in the 300 people involved in one study.Carnitine has been studied in various cardiometabolic conditions, with a bit of evidence pointing towards efficacy as an adjunct in heart disease and diabetes. However, there are insufficient trials to determine its efficacy.Carnitine has no effect on preventing mortality associated with cardiovascular conditions.Carnitine has no effect on serum lipids, except a possible lowering of LDL.Carnitine has no effect on most parameters in end stage kidney disease, however it possibly has an effect on c-reactive protein. The effects on mortality and disease outcome are unknown.
Carnitine provides additional source of energy rather than carbohydrate metabolism by converting fats into energy in cellular level which allow athletes to rely on their body fats as fuel as well as carbohydrate intake. Also, the amount of carnitine in a person’s system is related to the amount of glycogen found in the muscles. So muscle carnitine prevents the use of glycogen in the muscles. With this glycogen sparing effect, it becomes an anti-catabolic agent that athletes could benefit from.
The carnitine content of seminal fluid is directly related to sperm count and motility,suggesting that the compound might be of value in treating male infertility. Several studies indicate that carnitine supplementation may improve sperm quality,The reported benefits may relate to increased mitochondrial fatty-acid oxidation (providing more energy for sperm) and reduced cell death in the testes.
Several studies have approved the effectiveness of supplemental carnitine in the management of cardiac ischemia (restriction of blood flow to the heart) and peripheral arterial disease. In fact, levels of carnitine are low in the failing heart muscle, supplemental amounts might counteract the toxic effects of free fatty acids and improve carbohydrate metabolism. Carnitine has had anti-ischemic properties when given orally and by injection.
An important interaction between diet and the intestinal microbiome brings into play additional metabolic factors that aggravate atherosclerosis beyond dietary cholesterol. This may help to explain some benefits of the Mediterranean diet. Hazen’s group from the Cleveland Clinic reported that carnitine from animal flesh (four times as much in red meat as in fish or chicken), as well as phosphatidylcholine from egg yolk, are converted by intestinal bacteria to trimethylamine (the compound that causes uremic breath to smell fishy). Trimethylamine is oxidized in the liver to trimethylamine N-oxide (TMAO), which causes atherosclerosis in animal models. Patients in the top quartile of TMAO had a 2.5-fold increase in the 3-year risk of stroke, death, or myocardial infarction.
A key issue is that vegans who consumed L-carnitine did not produce TMAO because they did not have the intestinal bacteria that produce TMA from carnitine.
Chemotherapy and radiation treatment adverse effects such as fatigue, mood and sleep disturbances, are common in cancer patients. A deficiency in carnitine may also occur, some studies were done on cancer patients with deficiency of carnitine. Carnitine supplementation have showed normal blood levels of carnitine, enhancement in mood and sleep, and relieving of the fatigue caused by chemotherapy. Carnitine may be depleted in some cancer chemotherapy treatments. There is weak evidence from clinical trials that carnitine supplementation may be beneficial in treating cancer anorexia-cachexia syndrome.
Type 2 diabetes which is marked by insulin resistance may be associated with a defect in fatty acid oxidation in muscle. Several studies suggest that carnitine supplementation may a beneficial effect on glucose utilization and reduce diabetic neuropathy. However carnitine may also increase overall cardio-metabolic risk.
Generally HIV infected patients accumulate fat in some areas of the body and lose fat in other areas, besides having high blood levels of fats (hyperlipidemia) and insulin resistance which is known as the lipdystrophy syndrome. This syndrome causes a deficiency in L- carnitine which causes defects in fat metabolism in mitochondria. Supplementation with carnitine in HIV-infected individuals may slow the death of lymphocytes, reduce neuropathy and favorably affect blood lipid levels.
The kidneys contribute to overall homeostasis in the body, including carnitine levels. In the case of renal impairment, urinary elimination of carnitine increasing, endogenous synthesis decreasing, and poor nutrition as a result of disease-induced anorexia can result in carnitine deficiency. Carnitine blood levels and muscle stores can become very low, which may contribute to anemia, muscle weakness, fatigue, altered levels of blood fats, and heart disorders. Some studies have shown that supplementation of high doses of L-carnitine (often injected) may aid in anemia management.
|Identification||IR or nuclear magnetic resonance|
|Appearance||white crystal or crystalline powder|
|Specific rotation||-9.5~-11.0(10% aqueous solution)|
|pH-value||3.0~4.5(5% aqueous solution)|
|Residue on ignition||≤0.5%|
Contact Person: Pan Lin